Dr Linda Reiling is a senior postdoctoral researcher in Professor Beeson’s lab at the Burnet Institute in Melbourne. Her research investigates targets and effector mechanisms of antibodies involved in acquired protective immunity against the merozoite stage of P. falciparum infections. Currently, her work focuses on the role of complement-fixing antibodies and their role in protection from clinical disease. Her involvement in the ACREME will be in the sero-surveillance theme, where she will focus on the evaluation and optimization of antigen selection for monitoring ongoing exposure and transmission.Related Projects
Related Publications
- A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria
- Antibody targets on the surface of Plasmodium falciparum-infected erythrocytes that are associated with immunity to severe malaria in young children
- Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives
- Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
- Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against clinical malaria
- Identification and prioritization of merozoite antigens as targets of protective human immunity to falciparum malaria for vaccine and biomarker development
- Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
- Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria
- Plasmodium falciparum reticulocyte-binding homologues are targets of human inhibitory antibodies and play a role in immune evasion
- Targets of complement-fixing antibodies in protective immunity against malaria in children