Evaluating a Potential Dose-Sparing Self-Amplifying RNA Vaccine for Induction of Functional Antibodies to Blood-Stage Plasmodium falciparum Malaria
October 31, 2026
Introduction: Next-generation malaria vaccines are urgently needed to provide greater efficacy and longevity. Antibodies targeting blood-stage merozoites can confer protection…
Community patient follow-up as a part of P. vivax case management in Cambodia: a mixed methods study
September 29, 2026
Background Community health workers are key to improving global health. In Cambodia, a malaria-endemic country, village malaria workers (VMWs) have…
Anopheles salivary antibody biomarker outcomes to assess the effectiveness of topical repellent in Southeast Myanmar
September 21, 2026
Background Measurement of human antibodies against Anopheles salivary proteins that are injected during mosquito bites may serve as biomarkers of…
A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America
September 21, 2026
Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is…
Diagnostic accuracy of a malaria rapid diagnostic test compared with polymerase chain reaction in Lao People’s Democratic Republic: a secondary data analysis
September 17, 2026
Background Malaria rapid diagnostic tests (RDTs) are widely used in malaria endemic countries in both clinical and community settings for…
Targeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies
September 16, 2026
Introduction: Malaria is a leading health problem with high disease burden and mortality rates worldwide. Currently approved vaccines target the…
Splenic Tropism and Spleen-Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria
September 10, 2026
In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total-body parasite biomass. Whether splenic tropism also…
Protocol for IgG Antibody Measurements against Plasmodium vivax serological exposure markers using a Luminex assay
September 9, 2026
Quantifying antibodies against Plasmodium vivax enables the detection of both recent and past P. vivax exposure and may help identify individuals with clinically silent…
Community perceptions, trust, and experiences of malaria clinical research and participation in rural Cambodia
September 8, 2026
Introduction Understanding community perspectives on malaria treatment and research participation is important for designing ethically appropriate community engagement strategies, strengthening…
Protective immunity to clinical malaria is modified by the genetic diversity of P. falciparum antigens
September 5, 2026
Prioritising malaria vaccine targets requires understanding immunity to genetically and structurally diverse parasite antigens, influencing antibody measurements and durability. We…