Performance and feasibility of reactive surveillance and response strategies for malaria elimination in Vietnam: a mixed-methods study
August 7, 2023
Background: To enhance malaria elimination, Vietnam adopted a Reactive Surveillance and Response (RASR) Strategy in which malaria case notification and investigation…
Quantifying spatial heterogeneity of malaria in the endemic Papua region of Indonesia: Analysis of epidemiological surveillance data
August 5, 2023
Background: As control efforts progress towards elimination, malaria is likely to become more spatially concentrated in few local areas. The purpose…
A step forward for Plasmodium falciparum malaria transmission-blocking vaccines
July 24, 2023
There were an estimated 247 million clinical episodes and 619 000 deaths due to malaria in 2021. Stalled progress in reducing the…
An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria
July 20, 2023
Background: The artemisinins are potent and widely used antimalarial drugs that are eliminated rapidly. A simple concentration-effect pharmacometric model does not…
Characterizing antibody responses to mosquito salivary antigens of the Southeast Asian vectors of malaria and dengue with a human challenge model of controlled exposure: a protocol
July 11, 2023
Background: Measurement of antibody titers directed against mosquito salivary antigens in blood samples has been proposed as an outcome measure to…
Anopheles diversity, biting behaviour and transmission potential in forest and farm environments of Gia Lai province, Vietnam
July 5, 2023
Background: Despite recent reductions in Vietnam, malaria transmission persists in some areas in forests and farmlands where a high density of…
Anomaly Detection in Endemic Disease Surveillance Data Using Machine Learning Techniques
June 30, 2023
Disease surveillance is used to monitor ongoing control activities, detect early outbreaks, and inform intervention priorities and policies. However, data…
The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts
June 29, 2023
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting…
Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models
June 28, 2023
Background Evaluation of parasite clearance patterns in experimental human infection trials helps increase understanding of drug action. In a previously…
Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis
June 26, 2023
In areas of moderate to intense Plasmodium falciparum transmission, malaria in pregnancy remains a significant cause of low birth weight,…