Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: A cost-effectiveness analysis using a transmission model
January 9, 2024
Background Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine…
A cross-sectional study to ascertain malaria prevalence among asymptomatic travellers arriving on the Lihir Group of Islands, Papua New Guinea: implications for elimination efforts
November 29, 2023
Background The Lihir Islands of Papua New Guinea host a mining operation that has resulted in a mine-impacted zone (MIZ)…
Comparison of new computational method for spatial modelling of malaria
November 21, 2023
Geostatistical analysis of health data is increasingly used to model spatial variation in malaria prevalence, burden, and other metrics. Traditional…
Primaquine radical cure in patients with Plasmodium falciparum malaria in areas co-endemic for P falciparum and Plasmodium vivax (PRIMA): a multicentre, open-label, superiority randomised controlled trial
November 15, 2023
Background In areas co-endemic for Plasmodium vivax and Plasmodium falciparum there is an increased risk of P vivax parasitaemia following P falciparum malaria. Radical cure is currently only…
Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
October 10, 2023
Background Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax. This study investigated the effect of…
Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
September 22, 2023
Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal dosing regimen remains unclear. We undertook a systematic review and individual…
Sharing results with participants (and community) in malaria related research: Perspectives and experience from researchers
September 5, 2023
Results-sharing with participants or their communities after the completion of research is an essential element of ethical research. The main…
The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial
September 4, 2023
Symptoms reported following the administration of investigational drugs play an important role in decisions for registration and treatment guidelines. However,…
Evidence Based Optimal Dosing of Intravenous Artesunate in Children with Severe Falciparum Malaria
September 4, 2023
The majority of deaths from malaria are in young African children. Parenteral artesunate (ARS) is the first-line treatment for severe…
Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses
August 21, 2023
Primaquine (PQ) kills Plasmodium vivax hypnozoites but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We conducted…