Plasmodium falciparum reticulocyte-binding homologues are targets of human inhibitory antibodies and play a role in immune evasion
March 25, 2025
Antibodies targeting the blood-stage of Plasmodium falciparum play a critical role in naturally acquired immunity to malaria by limiting blood-stage parasitemia. One…
Performance of quantitative point-of-care tests to measure G6PD activity: An individual participant data meta-analysis
March 25, 2025
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the main risk factor for severe haemolysis following treatment with 8-aminoquinolines (8AQ). The World…
Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000–22: a spatial and temporal modelling study
March 5, 2025
Background Malaria remains a leading cause of illness and death globally, with countries in sub-Saharan Africa bearing a disproportionate burden….
Antibody correlates of risk of clinical malaria in an area of low and unstable malaria transmission in western Kenya
March 4, 2025
Background Defining antibody correlates of protection against clinical malaria in areas of low and unstable transmission is challenging because of…
Detrimental infant and maternal outcomes of undiagnosed asymptomatic malaria in pregnancy
February 24, 2025
Over 40% of the world’s population is at risk of malaria, yet progress in reducing the global burden has stalled…
The 1985 Plasmodium vivax malaria elimination campaign in Santa Catarina, Brazil: the feasibility of using serology amid other integrated tools in the last mile
February 21, 2025
This report outlines the process of malaria elimination in two municipalities, São Francisco do Sul and Araquari, located in Santa…
Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative study
January 13, 2025
Background In moderate-to-high malaria transmission regions, the World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP)…
Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics
January 13, 2025
Background Plasmodium vivax forms dormant liver stages (hypnozoites) that can reactivate weeks to months after primary infection. Radical cure requires a…
Facilitators, barriers and acceptability of malaria reactive surveillance and response strategies in Vietnam: a mixed-methods study
December 16, 2024
Introduction Vietnam has achieved significant reductions in its malaria caseload over the past decades and is progressing towards malaria elimination. To…
Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection
November 1, 2024
Background Human immune responses to infection and vaccination are heterogenous, driven by multiple factors including genetics, environmental exposures and personal…