A global mathematical model of climatic suitability for Plasmodium falciparum malaria
October 10, 2024
Climatic conditions are a key determinant of malaria transmission intensity, through their impacts on both the parasite and its mosquito…
Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis
September 27, 2024
Background: The 8-aminoquinolines, primaquine and tafenoquine, are the only available drugs for the radical cure of Plasmodium vivax hypnozoites. Previous evidence…
Primaquine for uncomplicated Plasmodium vivax malaria in children younger than 15 years: a systematic review and individual patient data meta-analysis
September 24, 2024
Background: Primaquine, the only widely available treatment to prevent relapsing Plasmodium vivax malaria, is produced as 15 mg tablets, and new…
Investigation of P. vivax elimination via mass drug administration: A simulation study
September 9, 2024
Plasmodium vivax is the most geographically widespread malaria parasite. P. vivax has the ability to remain dormant (as a hypnozoite) in the human…
A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites
August 22, 2024
Apical membrane antigen-1 (AMA1) is a conserved malarial vaccine candidate essential for the formation of tight junctions with the rhoptry…
The challenges of malaria elimination in the Asia–Pacific region
August 19, 2024
In the Asia–Pacific region, more than 2 billion people are at risk of malaria. The epidemiology of malaria is highly…
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites
August 8, 2024
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of antimalarial efficacy and transmission. Recurrent infections may arise from activation of dormant…
Antibody mechanisms of protection against malaria in RTS,S-vaccinated children: a post-hoc serological analysis of phase 2 trial
August 7, 2024
Background The RTS,S malaria vaccine is currently recommended for children aged 5–6 months in regions with moderate-to-high Plasmodium falciparum transmission. However, vaccination only…
Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia
July 19, 2024
Plasmodium vivax remains a challenge for malaria elimination since it forms dormant liver stages (hypnozoites) that can reactivate after initial infection….
Impact on pregnancy outcomes of intermittent preventive treatment with sulfadoxine-pyrimethamine in urban and peri-urban Papua New Guinea: a retrospective cohort study
July 5, 2024
Background Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) reduces malaria-attributable adverse pregnancy outcomes and may also prevent low birth…